Friedreich’s Ataxia News Forums Forums Research, Science, and Trials Frataxin Deficiency in FA May Ease by Raising Protein’s Levels, Early Study Says

  • Matthew Lafleur

    Member
    January 25, 2019 at 9:32 am

    I don’t mean to be a bummer. I should probably be super excited that any progress is being made…but part of me thinks, “This isn’t my first rodeo.” Seems like incremental steps have been all there is to see for twenty years. I’m ready for a breakthrough. Sorry, I need to be more optimistic, but those are my thoughts.

  • Shandra

    Member
    January 25, 2019 at 4:41 pm

    I thought this was interesting, because it takes a different route to rescuing Frataxin. I’ll explain.

    Our cells make proteins like this: DNA -> RNA -> Protein

    So normally Frataxin is made like this:

    Frataxin Gene (DNA) -> Frataxin mRNA -> Frataxin Protein

    Because of GAA repeats in the DNA, FA patients have trouble with the first step ( DNA -> RNA ), which is known as transcription. Since we don’t make sufficient Frataxin mRNA, we don’t have enough Frataxin protein. But, we do have some.

    The cool thing about this study is it takes a post-transcriptional approach. In other words, instead of trying to get around the issues caused by the GAA repeats in the DNA, the protein in the study (GRP75) works with the small amount of Frataxin we already have, and basically helps keep it around longer and get to the mitochondria where it can then do its job.

    It’s definitely preliminary work, but I think it’s pretty cool. Instead of trying to make our bodies produce more Frataxin, or simply mopping up the damage caused by not having much Frataxin, this research shows we might be able to just help the Frataxin we already have!

  • Shandra

    Member
    January 25, 2019 at 4:54 pm

    Here is the full paper, if anyone is interested in reading: https://drive.google.com/file/d/1qaEvn_0GQAbyvI0nVcaXGpaD7beigj8R/view?usp=sharing

    • Matthew Lafleur

      Member
      January 25, 2019 at 4:58 pm

      You are like our secret weapon and I am honored to have you here.

    • Frankie Perazzola

      Member
      January 26, 2019 at 4:13 pm

      I agree with Matt, we’re so fortunate!

Log in to reply.