Friedreich’s ataxia (FA) – a genetic condition that affects the nervous system and muscles – is caused by defects in a gene called frataxin (FXN). This gene encodes for a protein that is essential for the proper functioning of mitochondria, energy-producing factories within the cell.

Genetic cause of FA

The genetic defect that causes FA is an expansion of a GAA trinucleotide repeat. Each gene consists of a coding sequence made up of four chemical units called nucleotides – adenine (A), cytosine (C), guanine (G), and thymine (T).

In the FXN gene, there is a region where three nucleotides, GAA, are repeated several times (between 5 to 33 times). In people with FA, the number of repeats is increased (ranging from 66 repeats to more than 1000 repeats) in both copies of the FXN gene.

The length of the GAA trinucleotide repeat appears to be related to the age of onset, the degree of severity, and pace of progression of the symptoms; people with GAA segments repeated fewer than 300 times tend to have a later appearance of symptoms (after age 25) than those with larger GAA trinucleotide repeats.

Around two percent of people with FA have an expanded GAA trinucleotide repeat in one copy and a different kind of mutation in the other copy of the FXN gene. In most of these cases, the other mutation changes a single coding nucleotide, (called a point mutation), within the FXN gene.

Although it is not clear how these mutations cause FA, scientists think that the frataxin protein controls the production of energy in the mitochondria. Frataxin keeps iron in a bound form and provides it for the synthesis of mitochondrial enzymes used to produce energy. When frataxin is lacking, all of the iron is in the free form, which cannot be utilized for mitochondrial enzyme synthesis, resulting in a disruption in the production of energy. Free iron accumulates resulting in a buildup of harmful reactive molecules (free radicals), damaging and destroying the cells.

Since mitochondria is an essential source of energy, cells in the brain, spinal cord, and muscles, which require a lot of energy are particularly vulnerable to mitochondrial problems and become easily damaged by an insufficient energy supply, leading to the signs and symptoms of FA.

Inheritance

FA is inherited in an autosomal recessive manner, which means that an individual develops FA only when he or she carries genetic defects in both copies of the FXN gene, one copy inherited from each parent.

If an individual inherits one normal copy and one defective copy of the FXN gene, he or she shows no symptoms and is said to be a carrier. If both the parents are carriers, the risk of a child developing FA is 25 percent.

Note: Friedreich’s Ataxia News is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.