Problems in the somatosensory (sensory nervous) and auditory systems of patients with Friedreich’s ataxia are potential biomarkers of early sensory damage,…
Articles by Patricia Inácio, PhD
Although clinical manifestations of their disease varies widely, patients with most common types of spinocerebellar ataxias (SCA) experience a similar…
People with Friedreich’s ataxia lose the crucial capacity to move freely around age 25, according to a large and ongoing study by…
The European Union is supporting a number of projects focused on the natural history of several spinocerebellar ataxias, projects that look at…
The European Friedreich Ataxia Consortium for Translational Studies (EFACTS) group suggested specific outcome measures it found to be best suited to clinical…
Delivery of a small RNA molecule (microRNA), called let-7, directly into the brain rescued motor impairments in a mouse model…
Regular and long-term aerobic exercise — in this case, running — slowed the start of Friedreich’s ataxia symptoms and prevented metabolic abnormalities in a mouse…
In Friedreich’s ataxia, insufficient frataxin protein in cells impairs the ability of mitochondria to control the production of harmful reactive oxygen species,…
A new mouse model of Friedreich’s ataxia, detailed at IARC 2017, exhibits human features of the disease and has the potential…
New research, presented at IARC 2017, showed that the frataxin gene in cells taken from Friedreich’s ataxia patients produces…